Pharmacology Junior Researcher
Dompé is a leading Italian biopharmaceutical company focusing on the
development of innovative treatment solutions for rare and often orphan
diseases in areas with unmet treatment needs, such as diabetes, organ
transplants, ophthalmology and oncology. Dompé pursues this objective by
promoting and actively participating in a network made up of the best names in
each activity of the pharmaceutical industry, from research to development,
from production to marketing.
Main activities: The successful candidate will be responsible for:
ü Providing molecular
biology expertise throughout the drug discovery process;
ü Pro-actively
support ongoing drug discovery projects and Med Chem/Technology platform
groups;
ü Preparation of
scientific reports and articles;
ü Supporting drug
discovery efforts by swiftly delivering a thorough understanding of the
pharmacokinetics and metabolic fate of novel chemical entities, rapidly
characterizing the ADME properties of medicinal chemistry compounds, and
assessing PK/PD relationships of drug discovery candidates. The department
supports all aspects of metabolism and pharmacokinetics via in vitro and in
vivo studies to ensure delivery of compounds with good drug-like properties for
pre-clinical development;
ü Performing in
vitro/in vivo ADME assays and for data interpretation, report preparation and
presentation of results at group meetings;Developing robust molecular Mechanism
of Action with a variety of drug discovery project teams for the purposes of
lead discovery. Applying state of the art molecular and cell biology approaches
to elucidate the biological profile of small molecules regarding their targets,
off-targets and phenotypic outcome via an in-depth understanding of biological
networks, systems biology, bioinformatics;
ü Managing agreement
with Universities, CROs and Research Institutions to collaborate in R&D
Program.
Profile: The ideal candidate
will possess the following qualifications:
·
Ph.D. degree in Biomedical science, systems biology,
bioinformatics, Biochemistry or a related field;Experience in lead discovery
science extended by in-depth knowledge of structural biology, in-vitro biology
or a related scientific area;
·
excellent understanding of chemistry;
·
Understanding of up-to-date biological screening
paradigms like reporter assays, mRNA signatures, assays for transcription,
translation, stability, and post-translational modifications and high content
screens;Familiarity with life sciences software (R, Spotfire, Pipeline Pilot,
Knime, Cytoscape, GeneGo) is desirable;
·
Familiarity with compound databases, such as ChEMBL or
PubChem, and public bioinformatics databases;Excellent oral/written
communication skills in English;
·
Ability to assimilate information from a wide range of
sources e.g. scientific, technical, etc;
·
Ability to work independently and collaborate in multidisciplinary
teams locally and globally;
·
Strong analytical and problem-solving skills and
scientific creativity are essential;
·
Excellent problem solving skills for developing
creative solutions;
Type of contract:fixed term contract
Location: Naples
Per maggiori
informazioni e per candidarsi,
